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KMID : 0861120060100020051
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Korean Journal of Oriental Preventive Medicine
2006 Volume.10 No. 2 p.51 ~ p.62
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Rehmannia Radix(RR) Extracts Inhibit IGF-II Induced VEGF and HIF-1 Expressions in HaCaT Keratinocyte Cells
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Park Ung
Ko Seong-Gyu
Shin Yong-Cheol
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Abstract
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Psoriasis is a chronic skin disease characterized by angiogenesis. It has been reported that growth factor as vascular endothelial growth factor(VEGF) and insulin like growth factor(IGF) II are overexpressed in psoriatic epidermis. To investigate the inhibitory effects of IGF-II induced VEGF and HIF-1 expression by RR extracts, we performed MTS assay, western blots using HaCaT cells. RR extracts significantly reduced IGF-II induced HIF 1 protein level via MAPK pathway in HaCaT cells. Also, RR extracts inhibited IGF-II induced VEGF mRNA and protein expression levels in the HaCaT keratinocytes. These results suggest that inhibition of HIF-1 and VEGF expressions by RR extracts contributes to the anti angiogenic effects.
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KEYWORD
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Rehmannia Radix, Insulin-like growth factor-II, HIF-1, VEGF, Psoriasis
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